Job Description

Discovery Pharmaceutical Sciences (DPS) enables drug discovery and drug product development through application of pharmaceutical science to drug delivery research from target identification through clinical candidate selection for both small and large molecules as well as vaccines. Discovery Pharmaceutical Sciences influences molecular design of these clinical candidates through physicochemical property profiling and application of insights to better understand and resolve drug product developability risks. We further utilize our expertise to identify and develop and study prototype formulations intended for clinical use and deliver robust toxicology formulations. In aggregate our team enables the transition of optimized molecules from discovery to clinical formulation development with clinical formulation strategies in place.

Discovery Pharmaceutical Sciences is seeking a Sr Scientist to join our department. The successful candidate will be expected to work as part of teams that is focused on the discovery of novel therapeutics through support of molecular profiling, de-risking strategies, formulation development and communication across discovery functions and downstream to development partners. The main responsibilities will be to carryout critical biologics profiling and early formulation/preformulation development experiments. Development of novel drug delivery technologies will also occur. Opportunities to also support small molecules in a similar way will also be possible. The candidate will contribute in lab driving experimental execution applying scientific rigor. The candidate will have the opportunity to develop innovative research as well to further refine our workflows and applied science initiatives to keep the DPS team at the forefront of Pharmaceutics assessment at the discovery interface.

It is beneficial if the candidate possesses experience related to various aspects of drug product development (i.e. formulation and process development, biopharmaceutics, analytical methods, regulatory considerations, and competitive landscape) with a drive to apply novel technologies while working at the laboratory bench. Strong academic background will also be considered.

The successful candidate should have a demonstrated capability for implementing impactful innovation either in academia or industrial positions. Strong communication skills and good documentation practices are essential. The successful candidate will be able to work in a fast-paced team environment.

Minimum required education:

• Ph.D., M.S. with +3 years or BS with +7 years in pharmaceutical sciences, chemistry, chemical / biochemical engineering, or related disciplines.

Required Experience and Skills:

• Biologics characterization and formulation experience

• Excellent verbal and written communication skills are required.

• Demonstrated experience solving program challenges by leveraging strong scientific fundamentals in related subject areas including organic chemistry, analytical chemistry, physical chemistry, biopharmaceutics, process development, and/or engineering.

• Ability to work in a fast-paced team environment.

• Demonstrated patent and/or peer reviewed publication record

Preferred experience and skills:

• Candidates with experience in pre-clinical / clinical formulation development and physicochemical characterization are preferred.

• Advanced computation, data analysis, and visualization skills.

• Strong track record of patent applications / patents.

• Strong track record of external peer-reviewed publications.

• Demonstration of external scientific presence and influence.

• Small molecule and biologics experience

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Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as "remote".

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Available benefits include bonus eligibility, long term incentive if applicable, health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and sick days. A summary of benefits is listed here.

San Francisco Residents Only:We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

Los Angeles Residents Only:We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance

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Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

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Requisition ID:R346207